ea0004oc17 | Steroid hormone action | SFE2002
Tierney T
, Christian H
, Morris J
, Buckingham J
Annexin 1 (ANXA1) plays an essential role in the 'early-delayed' feedback effects of glucocorticoids (GCs) on ACTH release. Evidence that ANXA1 is externalised from pituitary cells in response to GCs, together with the finding that the protein is localised mainly to the folliculo-stellate (FS) cells, has led us to propose that ANXA1 is a paracrine mediator of GC action in the anterior pituitary. To address this hypothesis we have examined ANXA1-dependent GC actions in co-cultu...